Modular. Turnkey. Affordable.

Automation technology for all

Founded in 2019 in Paderborn, Germany, Unchained Robotics is an independent platform for automation technology for manufacturing processes in companies, particularly for small and medium-sized enterprises (SMEs).

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With our high-speed service, we ensure that all cost and quality targets are met.

Mladen Milicevic, Kevin Freise

CEO, CTO

Our mission

We aim to simplify and accelerate the process of finding, building, and buying automation solutions, making them more accessible, affordable, and understandable for all businesses.
Our goal is to remove the complexity often associated with robotics, ensuring that even businesses without large resources can adopt automation and remain competitive in a rapidly evolving industrial landscape.

Jan Ludwig

Senior Investment Manager

Industrial Tech
Supply-Chain Management

AI-powered solutions for engineers

Semorai offers manufacturing companies an AI-based quality engineer that enables them to automatically identify potential errors in the development phase and assess their risk.

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We enable AI-powered solutions for your engineering and quality management.

John Achim Holzhauer, Kanran Zhou

CEO, CTO

Our mission

Our mission is to empower manufacturing companies by automating complex engineering workflows and creating a private, comprehensive historical graph of their engineering knowledge. Our AI-based quality engineer helps identify potential errors in the development phase, assess risks, and provide a single source of truth, driving smarter, more efficient engineering processes.

Sebastian Pyzalski

Investment Manager

Investment Focus Areas

IT Infrastructure
Sales Intelligence
eCommerce
Security

Great content. Fast and easy.

Scalable AI-Driven Content Creation for B2B

Fyrfeed delivers ready-to-publish, high-quality content for B2B companies through a subscription service. The content is generated by a self-learning AI and refined by humans, all managed via the fyrfeed platform. This approach enables fully scalable, high-quality content creation.

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Our human-in-the-loop approach to AI is transforming content creation – it’s quicker and scalable, without sacrificing quality.

Dr. Thomas Lindemann, Benjamin Zengler, Ehud Avner

CEO, COO, CTO

Our mission

We want to empower B2B companies by offering scalable, high-quality content solutions that build trust, generate leads, and drive revenue. By blending artificial intelligence with human creativity, we aim to simplify content marketing, making it accessible and affordable for businesses of all sizes.

Sebastian Pyzalski

Investment Manager

Investment Focus Areas

IT Infrastructure
Sales Intelligence
eCommerce
Security

Rhythm is life

A stroke of genius

Preventicus develops products that enable smartphones and smartwatches to detect irregular heartbeats, thereby reducing the risk of stroke.

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Our technology makes many stroke cases avoidable.

Dr. Thomas Hübner

CEO

Our mission

At Preventicus, our mission is to revolutionize cardiac care by harnessing advanced digital technologies to detect and manage heart rhythm disorders, reducing the risk of stroke and supporting healthier aging for individuals worldwide.

Tom Villinger

CEO

Pest practice: innovative and sustainable food safety

Innovating pest control

traplinked specializes in pest control and food safety, producing intelligent hardware and software. Through its products, traplinked enables pest control companies to increase their efficiency and enhance food safety standards. Instead of relying on poisonous bait, a common method until now, traplinked’s products employ only sustainable methods to control pests.

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I’m proud to say that we’re revolutionizing pest control and food safety with intelligent, sustainable solutions. By eliminating the need for poisonous bait, our technology not only enhances efficiency for pest control companies, but also sets new standards for food safety.

Tim Kirchhof

CEO

Our mission

Our mission is to elevate pest management for food and healthcare companies in Germany, Europe, and around the world. In doing so, we aim to reduce the spread of diseases, minimize food waste, and prevent food contamination. We consider ourselves direct partners to pest control companies, businesses, end customers, and regulators.

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Constantly expanding the range of tools

In addition to developing our own hardware, we are focusing on building a comprehensive IoT platform for the industry. We are integrating third-party hardware into the platform to provide pest controllers with an interface where they can utilize all intelligent devices in pest control. The platform connects technicians with end customers, enabling a direct, real-time digital exchange between the property and the service provider. This allows us to empower technicians by continuously expanding the range of tools available to them, enhancing their ability to manage and resolve pest issues more effectively and efficiently.

Jan Ludwig

Senior Investment Manager

Industrial Tech
Supply-Chain Management

High-class medical technology

seleon develops and produces complex medical devices on behalf of customers and ensures their approval.

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Our mission is high-class medical technology and first-class service.

Frank-Martin Rammelt

Managing Director

Alexander Hofer

Principal

Revolutionizing the mRNA Technology

Your DNA/RNA expert in the field of modification for almost two decades

Since 2022, baseclick is provider in custom synthesis of mRNA for research and pre-clinical applications. Our team of experts transforms your mRNA design ranging from research tool to mRNA product development.

baseclick enables life science researchers to create better solutions in diagnostics, therapeutics and vaccines development through a proprietary click chemistry.

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Click technology holds the promise to revolutionize the mRNA Technology. One example is – ethynyl uridine (EU) – which is a derivate used to replace uridine in mRNA-based therapies and vaccines. EU-modified mRNA exhibits prolonged expression and confers similar low immunogenicity compared to the other uridine derivates such a pseudo-uridine and methyl-pseudo-uridine. Discoveries like these encourage us to demonstrate the advantages of our technology to pharmaceutical companies.

Dr. Thomas Frischmuth

CEO

Our mission

We are on a mission to change the way therapeutics and vaccines are developed and manufactured. By focusing on targeted delivery agents instead of lipid nanoparticles (LNPs), we leverage the significant benefits of our modified nucleic acid building blocks to pioneer novel therapies and compounds. Our goal is to develop treatments for disease patients and improve the lives of millions of people around the world.

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mRNA Configurator

Click technology holds the promise to revolutionize the mRNA Technology in drug development for cancer treatment, vaccine discovery and enables tailored manufactured mRNA with superior quality.

baseclick supplies diverse types of mRNA

– High quality products and services at competitive prices

– Custom tailored support to meet specific applications

– Wide variety of modification

– Affordable custom synthesis up to 10 mg scales of mRNA

5-Ethynyl uridine (5-EU)

An uridine derivate for replacement of uridine in mRNA-based therapies and vaccines. Modified mRNA shows prolonged expression and confers similar low immunogenicity compared to the other uridine derivates such a pseudo-uridine and methyl-pseudo-uridine.

Targeted delivery agent – Tri-GalNAc-DBCO

Tri-GalNAc-DBCO enables the possibility to click label an azide modified nucleic acid molecule with an Tri-GalNAc by strain-promoted Alkyne-Azide cycloaddition (SPAAC). The Tri-GalNAc structure is recognized by the cellular surface protein asialoglycoprotein receptor (ASGPR) and can be used for targeted delivery of biomolecules such as siRNA, ASOs, mRNA etc. into ASGPR expressing cells for example to liver cells.

Targeted delivery agent – Azido-PEG4-Trimannose

Azido-PEG4-Trimannose enables the possibility to click label an Alkyne or DBCO modified nucleic acids with an 3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside moity by CuAAC. The Trimannose structure is recognized by the mannose receptor and leads to transportation into the cell by internalized receptor mediated endocytosis. Therefore, this molecule offers a possibility for target delivery of biomolecules to the cell.

Targeted delivery agent – Tri-β-GalNAc-PEG3-Azide

Custom oligonucleotide

You are searching for individual oligonucleotides? baseclick is offering special DNAs, RNAs and even LNAs for your specific application. We are glad to provide you with a wide range of special modifications.

5-Ethynyluridine: A Bio-orthogonal Uridine Variant for mRNA-Based Therapies and Vaccines

The identification of pseudo- and N¹-methylpseudo-uridine (Ψ and mΨ, respectively) as immunosilent uridine analogues has propelled the development of mRNA-based vaccines and therapeutics. Here, we have characterised another uridine analogue, 5-ethynyluridine (EU), which has an ethynyl moiety. We show that this uridine analogue does not cause immune activation in human macrophages, as it does not induce interleukin-6 secretion or expression of the inflammatory and antiviral genes MX1, PKR, and TAP2. Moreover, EU allows for prolonged expression, as shown with mRNA coding for yellow fluorescent protein (YFP). Side-by-side comparisons of EU with unmodified, Ψ, and mΨ revealed that EU-modified mRNA is expressed at lower levels, but confers similar stability and low immunogenicity to the other uridine analogues. Furthermore, structure analysis of modified mRNAs suggests that the observed phenotype is largely independent of RNA folding. Thus, EU is a potential candidate for RNA-based vaccines and therapeutics.

Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage

Recent studies of severe acute inflammatory lung disease including COVID-19 identify macrophages to drive pulmonary hyperinflammation and long-term damage such as fibrosis. Here, we report on the development of a first-in-class, carbohydrate-coupled inhibitor of microRNA-21 (RCS-21), as a therapeutic means against pulmonary hyperinflammation and fibrosis. MicroRNA-21 is among the strongest upregulated microRNAs in human COVID-19 and in mice with acute inflammatory lung damage, and it is the strongest expressed microRNA in pulmonary macrophages. Chemical linkage of a microRNA-21 inhibitor to trimannose achieves rapid and specific delivery to macrophages upon inhalation in mice. RCS-21 reverses pathological activation of macrophages and prevents pulmonary dysfunction and fibrosis after acute lung damage in mice. In human lung tissue infected with SARS-CoV-2 ex vivo, RCS-21 effectively prevents the exaggerated inflammatory response. Our data imply trimannose-coupling for effective and selective delivery of inhaled oligonucleotides to pulmonary macrophages and report on a first mannose-coupled candidate therapeutic for COVID-19.

Alexander Hofer

Principal

The xeno-free future of cell therapy

ELAREM™ Human Platelet Lysate (HPL)

PL BioScience creates xeno-free cell culture supplements for cell research and therapy development through an ethical and safe production process. Our ELAREM™ HPL platform is crafted from pooled, upcycled transfusion-approved platelet units, providing optimal conditions for cell expansion.

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We deliver cell solutions by innovating on cell culture.

Hatim Hemeda, Christian Wilkes

CEO, CFO

Our mission

At PL BioScience, we are dedicated to bridging the gap between research and clinical applications. Our mission is to advance regenerative medicine with our animal-free cell culture tools, producing human Platelet Lysates that have the potential to elevate both stem cell research and therapy to the next level.

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ELAREM™ Perform-FD PLUS

Available in GMP and Research Grades
Fibrinogen-deplated for convenience
EU origin product with 30 years of donor traceability

Tom Villinger

CEO

The world’s first actuator with a sixth sense

Following the Genius of Nature

MetisMotion manufactures modular actuator systems based on the patented naXture technology. Developed and designed according to a unique model from nature: the human muscle.

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We have the answer to the question of intelligent and clean actuators.

Patrick Fröse Wolfgang, Zöls Georg Bachmaier

Founders & Managing Directors

Our mission

We learn from the best! With our naXture technology, we combine the most effective features from existing drive technologies with the growing demands for efficiency and sustainability, and translate them into solutions and systems tailored to specific customers.

Patrick Krönlein

Principal

Investment Focus Areas

Software Infra
Resilience
Deep Tech

A heartbeat ahead

Resusitec develops, produces and markets cutting-edge technology for emergency and intensive care medicine to ensure safe patient care.

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We deliver the next level of ECPR.

Jörg Ronde, Dr. Christoph Benk, Dr. Thomas Kraft

Alexander Hofer

Principal